The main problem with the single mold press trial is that the difference is likely small enough to be measurable only by very accurate equipment....
If I'm doing a 6 in wheel and pressing at 4 psi, I'll need 113 pounds. My bathroom scale has 1 lb gradations, so I should be able to detect about 0.5 lbs in difference. If the difference is less than that--so that I can't detect any difference--then we could reasonably say the maximum load lost represents less that 0.5% per cheese.
Below is the stack size and % difference between 1st and last cheese:
So, this brings up a couple of questions. How many cheeses are put in a commercial horizontal cheese press? How much of a difference in pressure is cause for concern?
Recall this is the maximum loss possible based on my inability to measure smaller differences than 0.5 lbs. If the actual loss across a single cheese is less, the overall loss will, also be less.