I continue to be curious about this topic as using whey from the previous day's cheese making is traditional here in Brazil as well as Portugal and other locations.
Brazil's famous Serra da Canastra and Serro are recipes brought here from Portugal and the Azores and all use whey from the first pressing to culture the following day's production.
I know that the possibility of contamination is huge but they have been producing consistent quality for centuries.
Is Mother nature providing control?, is the salt in the first pressing providing protection?
Over the centuries, to the present, rennet was and is from an amazing variety of animals, to the point that most recipes mention only that the rennet be animal, Capibara, lizard, goat even armadillo are used to make rennet, depending upon the region. There are also a wide variety of native plants used for rennet as well.
These cheeses have a sharp "bite" if properly aged and it is the "pingo" or "drop of whey" from the previous days cheese that is given credit for this.